Jiang et al. (2021)in vitro research demonstrated that GSC-derived miR-944 suppresses HUVECs migration, proliferation, and tube formation. In mouse studies, the researchers found that agomiR-944 (a miR-944 agonist) significantly reduced tumor growth and angiogenesis. Exosomes derived from GSCs carry a miRNA called miR-944, which reduces VEGFC expression and inhibits the AKT/ERK signaling pathway in HUVECs and in xenograft glioma cell tumors (Jiang et al., 2021). This evidence concerns the gene AKT1 and central nervous system cancer.