The mechanism involves the formation of the GRP75/78-RHAMM complex, which binds to hyaluronic acid-mediated motility receptor (RHAMM) associated with the progression and metastasis of cancer, and interacts with microtubules to stabilize them during the interphase, preventing microtubule depolymerization and promoting the progression of mitosis (49, 50). This evidence concerns the gene HSPA9 and cancer.