It was also demonstrated that HOTAIR had higher expression in K562 and KCL-22 cells compared to bone marrow mononuclear cells, accompanied by lower expression of PTEN, and functional results indicated that HOTAIR downregulation reduces the proliferation, colony formation, and cell cycle progression while increasing the apoptosis rate of CML cells (78). The gene discussed is PTEN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.