A recent study showed that in 29 MA cases among 40 commonly mutated genes detected by whole-genome sequencing and verified by next-generation sequencing, KMT2C and BCOR were common with and without SO, whereas MAGEC1 and KDM6B were strongly associated with SO, and that the frequent gene mutation rate of approximately 33% of MA with SO was higher than that without SO (11%) (16). The gene discussed is KDM6B; the disease is microtia.