Various stem cell types, such as mesenchymal stem cells, bone marrow mononuclear cells, cardiosphere-derived cells, c-kit-positive cardiac cells, bone marrow CD34+ and CD133+ cells, and adipose-derived stem cells, are utilized for the treatment of heart diseases, while the autologous bone marrow-derived mesenchymal stem cells are the most commonly used. The gene discussed is PROM1; the disease is heart disorder.