AIM2 and experimental autoimmune encephalomyelitis: (232) that AIM2 negatively regulates the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and that this effect is independent of the activation of inflammasome.AIM2 deficiency enhances the activation of microglia and infiltration of peripheral immune cells into the CNS, thereby promoting neuroinflammation and demyelination during EAE.