SIRT1 and cervical cancer: Highly expressed SIRT1 in HPV-infected cervical cancer cells inhibited NF-κb-driven transcription of the AIM2 gene by destabilizing RELB mRNA and eliminated AIM2 inflammasome-mediated antiviral immunity, which allowed cervical cancer cells to continue to grow, suggesting that AIM2 exerts a tumor-suppressor role in cervical cancer (230).