(39), local disruption of the nuclear membrane induced by tumour treatment fields (TTFields) resulted in the release of a large number of micronuclei clusters into the cytoplasm, which strongly recruited and activated the two major DNA sensors cGAS and AIM2 and their corresponding cGAS/STING and AIM2/Caspase-1 inflammasomes, resulting in the production of pro-inflammatory cytokines, type I interferons (T1IFNs) and T1IFN-responsive genes (T1IRGs).MN is more common in patients and models of autoimmune and inflammatory diseases, suggesting that MN may be a source of immunostimulatory DNA (40). Here, CASP1 is linked to neoplasm.