CGAS and autoimmune disease: (145) To inhibit the excessive pro-inflammatory response associated with cGAS-STING overactivation in some autoimmune diseases, nanomedicinal hydrogels (NiH) were designed, which co-delivered the cGAS inhibitor RU.521 (RU) and cationic nanoparticles (cNPs) that scavenge free DNA (cfDNA) to draining lymph nodes (LNs), for systemic RA immunotherapy for Immunosuppression.