(145) To inhibit the excessive pro-inflammatory response associated with cGAS-STING overactivation in some autoimmune diseases, nanomedicinal hydrogels (NiH) were designed, which co-delivered the cGAS inhibitor RU.521 (RU) and cationic nanoparticles (cNPs) that scavenge free DNA (cfDNA) to draining lymph nodes (LNs), for systemic RA immunotherapy for Immunosuppression. The gene discussed is STING1; the disease is autoimmune disease.