observed that NETs significantly enhanced the inflammatory response in RA and osteoarthritic (OA) synovial fibroblasts, including the induction of IL-6, IL-8, chemokines and adhesion molecules, and in turn, the inflammatory factors IL-17A, IL-18, and TNF-a induced NETosis in RA neutrophils (110). This evidence concerns the gene IL18 and rheumatoid arthritis.