Chung et al.’s study found (216) that EFLA 945 significantly inhibited apoptosis-associated speckled proteins triggered by the AIM2 agonist poly(dA:dT) (CARD(ASC)-containing oligomerization), caspase-1 activation, and secretion of IL-1β and IL-18 by blocking the entry of DNA into THP-1-derived macrophages and ameliorated the severity of psoriasis in an in vivo mouse model. This evidence concerns the gene AIM2 and psoriasis.