Additionally, AIM2 knockdown inhibited TNF-α-induced expression of IL-6, IL-8, CCL2, MMP-1, MMP-3, and MMP-13, which reduces TNF-α stimulation-induced AKT phosphorylation, thereby attenuating RA synovial inflammation and joint damage (253). The gene discussed is AKT1; the disease is rheumatoid arthritis.