The production of MN has been linked to oxidative stress, DNA damage, and other factors.RA patients have elevated plasma levels of MDA, and reduced levels of GSH-Px and SOD, reflecting a higher degree of oxidative stress, a situation which may impair genetic stability in RA patients, as reflected by the fact that the genetic stability of RA patients is compromised. This evidence concerns the gene SOD1 and rheumatoid arthritis.