FOXO1 and rheumatoid arthritis: (142) showed that cytoplasmic dsDNA-induced activation of cGAS/STING induced mtROS production, leading to MST1 phosphorylation and subsequent FOXO1 phosphorylation and nuclear translocation in RA FLSs, which enhanced FOXO1 transcriptional regulation of polarity- and migration-related genes and facilitated in vitro migration and invasion of RA FLSs.