Moreover, monocytes pretreated with RA serum with high disease activity (DAS28>5.1) showed higher expression of GSDMD, with enhanced cleavage of GSDMD proteins and release of IL-1β and IL-6, compared with RA serum with low disease activity (DAS28<2.6) (288). The gene discussed is GSDMD; the disease is rheumatoid arthritis.