These include receptors of the GPCR signaling pathway (36, 37), which are associated with the immunopathogenesis of cardiological and neurological autoimmunity, including dysautonomia and POTS; nuclear antigens (27), which are linked to rheumatological symptoms, lupus, and vasculitis; CCP and TG (38), associated with rheumatoid arthritis and coeliac disease, respectively; DSG2 (39), related to cardiac pathology; and sex-specific antigens (40), which are connected to a wide range of long COVID symptoms. The gene discussed is DSG2; the disease is postural orthostatic tachycardia syndrome.