MYC and hepatocellular carcinoma: In HCC TME, enriched with cytokines and extracellular vesicles, various factors drive TAM polarization such as Wnt ligand secretion by tumor cells activates the Wnt/β-catenin pathway in macrophages, triggering β-catenin nuclear translocation and upregulating C-MYC transcription, thereby promoting M2-TAM polarization (75).