Furthermore, TAMs themselves are influenced by signaling pathways like the phosphorylation of LAMTOR1, which interacts with Exo70 and other components to enhance the secretion of TGF-β1, which secret fuels a positive feedback loop, promoting TAM polarization towards a more immunosuppressive phenotype, marked by an increase in Tregs and a decrease in CD8+ T cells within the HCC tumor microenvironment (159). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.