LMP1-upregulated B7-H3 expression suppresses NK cell cytotoxicity via the PI3K/AKT/mTOR signaling pathway. Knockdown of B7-H3 in tumor cells, combined with anti-PD-L1 treatment, restored NK cell function and enhanced cytotoxicity against NPC cells. The gene discussed is AKT1; the disease is nasopharyngeal carcinoma.