They also exhibit higher expression of inhibitory molecules such as NKG2A/CD94, lower expression of CD16 (receptor that facilitates ADCC), CD57 (NK cell maturation marker), and KIR2DL4 (activating receptor), and reduced production of perforin, granzyme B, IFN-γ, and cell surface FasL and TRAIL, reducing cytotoxicity against tumour cells (146). This evidence concerns the gene PRF1 and neoplasm.