The upregulated genes were involved in transcriptional and epigenetic regulation, including multiple subunits of the SWI/SNF chromatin remodeling complex (ARID1A, ARID1B, and SMARCC2), as well as NCOA6, a multifunctional transcriptional coactivator and component of the Set1-like H3K4-methyltransferase complex ASCOM, all of which have been shown to play a role in the pathogenesis of cancer (25). The gene discussed is ARID1A; the disease is cancer.