HMGA1 and cancer: Among the upregulated genes are several cancer-related transcriptional regulators including PPARD (28) and HMGA1 (29), key regulators of lipid pathways (30), transcription elongation factor SPT6 (SUPT6H), SOAT2, an enzyme involved in lipoprotein and cholesterol regulation, and GPD1, an enzyme that plays a key role in lipid metabolism, are also upregulated in responders.