Furthermore, adipose tissues have been shown to produce various soluble tumor necrosis factor-alpha receptors, which may attenuate the negative biological effects of TNF-a and other cytokines such as interleukin-6 and interleukin-8 released during periods of inflammation, which may increase the risk of death from cardiovascular disease [42]. The gene discussed is TNFRSF1A; the disease is cardiovascular disorder.