In addition, studies show that octamer-binding transcription factor (OCT4) expression is driven by HIF-2α through miR-130/131-mediated downregulation of peroxisome proliferator-activated receptor-γ (PPARγ), resulting in increased proliferation of PAECs and PASMCs in PAH (43). Here, EPAS1 is linked to pulmonary arterial hypertension.