CTNNB1 and neoplasm: One of our other patients, a 71-year-old woman with metastatic adenocarcinoma of the right lung, had a liquid biopsy with ctDNA tumor fraction of <1% with a detectable mutation in TP53. Her tumor NGS showed a KRASG12Dmutation and co-mutations in CTNNB1 and ARID1A. This is a very similar scenario to the patient discussed in this case report, again highlighting the importance of tumor fraction reporting.