SOD1 and amyotrophic lateral sclerosis: Previous studies for instance reported reduced expression of calcium-buffering in post-mortem isolated MNs in ALS patients (Alexianu et al., 1994), an increase in persistent sodium currents in spinal and cortical MNs in SOD1 mice (Pieri et al., 2009; Kuo et al., 2005; Kuo et al., 2004), and alterations of the fast transient sodium currents generated by Nav channels in spinal MNs in SOD1 mice (Zona et al., 2006).