In this study, we detailed a mouse strain, created by crossbreeding the GFAP/EGFP (Nolte et al., 2001) with the SOD1(G93A) model of ALS (Gurney et al., 1994), resulting in mice with ALS-like phenotype and fluorescently labeled astrocytes. Here, GFAP is linked to amyotrophic lateral sclerosis.