The phenols from areca nut seed was reported that it could relieve osteoporosis through regulating the expression of osteoprotegerin (OPG), RANKL, LDL-receptor relater protein 5 (LRP5), bone morphogenetic protein-2 (BMP2) and β-catenin related to the Wnt/β-catenin pathway in VOX-induced OP rats (8). The gene discussed is TNFSF11; the disease is osteoporosis.