The SNPs of genes encoding proteins such as IL10RB (Interleukin 10 Receptor Subunit Beta), CCR1 (C-C Chemokine Receptor Type 1), IF-NAR2 (Interferon Alpha and Beta Receptor Subunit 2), PDE4A (Phosphodiesterase 4A), ACE2 (Angiotensin I Converting Enzyme 2), and CCR5 (C-C Chemokine Receptor Type 5) were also found to be associated with COVID-19 in the study by Gaziano et al47, as well as those encoding the protein Gp13046 or ACE2 expression.49 This evidence concerns the gene ACE2 and COVID-19.