DES and familial dilated cardiomyopathy: Over 50 genes have been linked to DCM, in particular, the most involved are myosin heavy chain 7 (MYH7), dystrophin gene (DMD), desmoplakin (DSP), vinculin (VCL), desmin (DES), sodium voltage-gated channel alpha subunit 5 (SCN5A), actin alpha cardiac muscle 1 (ACTC1), nexilin F-actin binding protein (NEXN), troponin T (TNNT2), RNA-binding motif protein 20 (RBM20), phospholamban (PLN), Lamin A/C (LMNA), tropomyosin 1 (TPM1), troponin C1 (TNNC1), BAG family molecular chaperone regulator 3 (BAG3) and titin (TTN) [10,41,42,43,44,45].