At the inflammatory level, since diabetes is considered a typical proinflammatory state accompanied by increased cellular inflammation [28], the close correlation found between PRCP and ICAM3 plasma levels (documented both by linear correlation in Figure 3 and by the tight vector angle in PCA plot of Figure 2) supports their role in endothelial dysfunction induced by glucotoxicity. The gene discussed is ICAM3; the disease is diabetes mellitus.