RPTOR and tauopathy: To investigate whether Raptor knockdown could ameliorate cognitive deficits in the P301S mouse model of tauopathy, we bilaterally injected adeno-associated virus (AAV) vectors expressing either shRNA targeting Raptor (pAAV-U6-shRNA(Rptor)-CMV-EGFP-WPRE) or a control shRNA (pAAV-U6-shRNA(NC2)-CMV-EGFP-WPRE) into the hippocampal CA3 region of 6-month-old P301S mice.