Gut dysbiosis in PD mice associates with the erosion of SFB and the increase of Enterobacteriaceae from the ileal mucosa that may correlate with the disruption of intestinal epithelial cell signaling, leading to an increase in CD11b+ macrophages or dendritic cells in the ileum lamina propria of PD mice (Fig. 3A, B). Here, ITGAM is linked to Parkinson disease.