To determine the role of RIP1 in glaucoma, RGC survival, and function were monitored in RIP1-kinase-dead (RIP1-KD, Ripk1D138N) mice with optic nerve crush (ONC) injury, which are used to model relevant features of retrograde glaucomatous stress (Supplementary Fig. 1A–C). This evidence concerns the gene RIPK1 and glaucoma.