Given the variable severity of IDD and rareness of malformations we identify in BCL11A-IDD, we posit that individuals reported to have loss of function inducing variants in gnomAD had a mild neurodevelopmental phenotype not precluding their inclusion in gnomAD cohorts, and/or the variants have minimal phenotypic impact due to their C-terminal location or sparing of BCL11A-XL. Here, BCL11A is linked to intervertebral disk degenerative disorder.