Wang F et al. underscore the capacity of lncRNA CADM1-AS1 to hinder HCC proliferation via AKT/GSK-3β signaling pathway, thereby orchestrating alterations in key cell cycle regulators to prevent the transition from G0/G1 to S phase transition, both in culture as well as mouse model of HCC [29]. Here, GSK3B is linked to hepatocellular carcinoma.