LZTR1 and hepatocellular carcinoma: Moreover, research has shown that elevated expression of HOTAIR is associated with sorafenib resistance in HCC cells [24, 25], A recently identified lncRNA, LL22NC03-N14H11.1 has been shown to interact with the Myb proto-oncogene (c-Myb) to reduce expression of leucine zipper-like transcription regulator 1 (LZTR1), hence decreasing the ubiquitination of H-RAS thereby, activating MAPK signalling pathway [26].