GAS5 and GAS5-AS1 are the only two lncRNAs that are downregulated in the HCC tissues, whereas the other lncRNAs which include MALAT-1, HOXB-AS1, HOTAIR, TUG1, MKLN-1, etc. are the lncRNAs which are upregulated in HCC tissues when compared to normal tissues and their expression are related to poor prognosis and poor overall survival. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.