Recently, Zhang H et al. have underscored that SNHG1, a lncRNA regulated by Kruppel-like factor (KLF4), operates to dampen ER stress-induced apoptosis and propel the development of gliomas by orchestrating the elevation of inhibitor of apoptosis (IAP) family protein baculoviral IAP repeat containing 3(BIRC3) [41]. Here, BIRC3 is linked to central nervous system cancer.