YAP-1 can bind to HIF-1α and maintain its stability to activate the aerobic glycolysis, but a study by Guo et al. for the first time proved that MKLN-1 causes YAP-1 accumulation and hence tumor progression, thus can be used as an upstream factor in HCC for its diagnosis and prognosis [74]. Here, YAP1 is linked to hepatocellular carcinoma.