However, OPN protein levels in MIC β1 integrin-deficient mammary glands at 2 weeks post-induction and early invasive MIC β1 integrin-deficient dormant tumors remained comparable to their MIC WT counterparts, arguing that OPN protein level is only elevated upon tumor recurrence (Supplementary Fig. 2a–d). The gene discussed is SPP1; the disease is neoplasm.