ITM2B and Alzheimer disease: The 48/121 DEGs that overlapped between rh Bri2 BRICHOS R221E vs veh treated WT mice and rh Bri2 BRICHOS R221E vs veh treated AppNL-G-F mice and also are differentially regulated in AppNL-G-F vs WT mice (Fig. 6D) represent several different biological processes without known relevance for AD-like pathology (Supplementary Excel file 1).