Since PCLAF also promotes lung tumorigenesis20, to minimize the risk of tumorigenesis by drug candidates, we excluded any drugs that were identified from the Pclaf/PCLAF depleted gene sets of the mouse lung tumors (KrasG12D/Trp53-/-; KP) and human (H1792) lung cancer cell lines (Fig. 6A, B, and Supplementary Data 4 and 5)20, which identified four drugs (phenelzine, trimethobenzamide, ibuprofen, and RS 23597-190) (Fig. 6B). This evidence concerns the gene TP53 and lung cancer.