DAM has elevated expression of genes involved in lipid metabolism and phagocytosis, corresponding to the need for plaque clearance in Alzheimer’s disease26, but our study revealed increased neuroblast phagocytosis by microglia in stroke-associated SVZ cluster 4 and predicted cross-communication with SVZ NSPCs via the ligand-receptor pair ApoE–Lrp8. Here, LRP8 is linked to stroke disorder.