PRNP and scrapie: Comparison of our current structure to the several other recently determined infectious prion structures indicates that it shares a number of general cross-sectional features with the rodent-adapted scrapie prion strains: an ordered core spanned by ~ 137 residues of a single PrP monomer; a staggered central interface between N- and C-lobes (Fig. 5); a disulfide arch with a low resolution tip; and outwardly projecting N-linked glycans and GPI anchor.