A total of 119 participants with APOL1 high-risk genotypes underwent DNA methylation profiling, consisting of 27 cases with CKD (14 biopsy-confirmed APOL1 nephropathy: HIVAN 10, FSGS 3, hypertension 1), 55 controls with persistently normal kidney function and 37 individuals with previous acute kidney injury or mild CKD. Here, APOL1 is linked to Hypertension.