When these analyses were restricted to African-Americans (404 CKD cases and 4263 controls), these CpG sites remained concordant in direction of association, with three signals showing nominally significant associations (P < .05; cg14849578 (SCARB1), cg22959742 (FRMD4A), cg24791666 (CSRNP1)). This evidence concerns the gene CSRNP1 and chronic kidney disease.