Its abnormal expression leads to malignant proliferation and metastasis of GC cells, inhibition of apoptosis and enhancement of chemotherapy resistance, suggesting that HCP5 has a carcinogenic effect and plays an important role in the occurrence of GC.[19, 20, 21] Nonetheless, the mechanistic underpinnings of HCP5 primarily entail functioning as a microRNA sponge that regulates the expression of downstream target genes.[22, 23] Further investigation is warranted to elucidate the coding potential of HCP5 in GC, as well as the biological functions and underlying mechanisms of its products. This evidence concerns the gene HCP5 and gastric cancer.