HCP5 has been found to be over‐expressed in a variety of tumors, including GC and esophageal squamous cell carcinomas, and to possess cancer‐promoting functions by exerting competing endogenous RNA (ceRNA) activity or interacting with proteins such as UTP3.[20, 54, 55] Here, we have demonstrated that the new protein HCP5‐132aa produced by HCP5 is upregulated in GC tissues and cells, and that high expression of HCP5‐132aa is associated with poor prognosis in patients with GC. The gene discussed is HCP5; the disease is esophageal squamous cell carcinoma.