SLC7A11, a component of system Xc−, has recently been reported to be upregulated in several human cancers, including GC, contributing to various biological processes that facilitate tumor progression, partly by inhibiting ferroptosis.[31] Furthermore, we observed a significant downregulation of G6PD, another ferroptosis‐associated gene, in GC cells following HCP5‐132aa knockout or YBX1 knockdown. This evidence concerns the gene YBX1 and gastric cancer.