CSF2 and neoplasm: Herein, it is observed that apoptosis of TANs is significantly delayed owing to induction by tumor‐derived G‐CSF and GM‐CSF through the activation of the PI3K‐AKT signaling pathway, upregulation of anti‐apoptotic Mcl‐1 expression, and downregulation of activated Caspase‐3 levels.