T cells, particularly CD8+ T cells, predominantly suppress tumor growth.[46, 47] Previous studies have reported that neutrophils exhibit high plasticity and remarkable adaptive abilities in response to different TME cues.[48] Tumor‐infiltrating neutrophils can acquire a T cell suppressor phenotype characterized by inhibition of T cell activation and proliferation.[49] Consistent with these findings, we observed that both tumor‐infiltrating neutrophils and TTCS‐conditioned circulating neutrophils showed suppressive effects on activated CD8+ T cell proliferation and IFN‐γ secretion. The gene discussed is CD8A; the disease is neoplasm.