PDGFRA and hyperinsulinemic hypoglycemia, familial, 4: In addition, the proportion of patients harboring genomic alterations associated with homologous recombination deficiency (small-scale variant or loss of ATM, BRCA2, and RAD51X) was higher in KIT/PDGFRA-mutated GISTs than in KIT/PDGFRA wild-type GISTs (10% v 4%, respectively; P = .467).