Dysregulation of the Notch signaling is involved in many hematological and solid malignancies.[5, 25] Notch1 is a well‐characterized oncoprotein in T‐ALL, while Notch1 is believed to be a tumor suppressor in AML.[5, 26] In T‐ALL, there are several reports proposing different molecular mechanisms involved in the leukemogenesis of Notch1. The gene discussed is NOTCH1; the disease is acute myeloid leukemia.