To test this hypothesis, we performed a rescue experiment, where we administered recombinant IL-18 (rIL-18) at 10μg/kg or PBS to Cx3cr1+Casp1 deficient mice at 1 hour post-infection and on days 1, 3, 5, and 7 post-infection (Fig 5A). This evidence concerns the gene CX3CR1 and infection.