In contrast, expression of mLama4MHC-I or mAlg8MHC-I neoAg along with mItgb1MHC-II neoAg rendered YUMM1.7 melanoma lines (Y1.7LI and Y1.7AI) sensitive to anti-CTLA-4 ICT (Figure 1A). The gene discussed is CTLA4; the disease is melanoma.