Comparison with published gene signatures of neoAg-specific CD4 T cells indicated that ICOShiBhlhe40hiCD4Th1, CD4Th1_A, and CD4Th1_B displayed enrichment in signatures of tumor-specific CD4 T cells (Lowery_2022_CD4.neoAgTCR) derived from transcriptomic analysis of neoAg-specific TCR clonotypes from human metastatic tumor samples61 (Figure 5C). The gene discussed is CD4; the disease is neoplasm.