Interestingly, its expression showed no correlation with prognosis in lung squamous cell carcinoma (LUSC), colon cancer (COAD), and liver cancer (LIHC) (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI178079DS1), suggesting that the prognostic importance of Ku70 expression is influenced by the unique tumor microenvironment (TME) of LUAD. Here, XRCC6 is linked to squamous cell lung carcinoma.