It is critical to develop targeted interventions to address barriers that impede appropriate BRCA1/2 referrals to genetic counselors from primary care clinicians following US Preventive Services Task Force (USPSTF) guidelines.1 We conducted a cluster randomized clinical trial (Genomics for Breast Cancer in Primary Care [BEATRICE]) of patient and clinician decision support to increase BRCA1/2 genetic referrals based on USPSTF guidelines. This evidence concerns the gene BRCA1 and breast cancer.