IL1B and periodontitis: The study showed a highly positive correlation between IL-1β levels in patients with periodontitis and clinical indices such as PD, BOP, gingival recession, and dental plaque.33 In the present study, the decrease in IL-1β was more pronounced after 6 weeks of treatment with SRP combined with Nd: YAG, and the combination treatment statisically significantly reduced the levels of PD and BOP, confirming the idea that IL-1β is positively correlated with PD and BOP.