IL-8 is a pro-inflammatory cytokine that plays a crucial role in the recruitment and activation of neutrophils, contributing to the inflammatory response in periodontal diseases.14 A recent study demonstrated that the efficacy of periodontal treatment is directly linked to a drop in salivary IL-8 levels.21 The observed reduction in IL-8 levels in our study suggests that therapeutic fasting may have anti-inflammatory effects in the oral cavity. The gene discussed is CXCL8; the disease is periodontal disorder.