GHRL and obesity due to melanocortin 4 receptor deficiency: Treatment with acylated ghrelin (acyl-ghrelin), the bioactive form, has been associated with better functional recovery of cultured neurons exposed to hypoxia under experimental in vitro conditions and improved synapse recovery.8 In rat models, ghrelin has shown promising results in preventing neuronal apoptosis after cardiac arrest and improving neurological recovery, especially in the hippocampus.9,10 Ghrelin has been administered in healthy participants as well as patients with obesity, diabetes, neurodegenerative diseases, and cardiac failure.