Although we have explored the role of FUNDC1 in AKI, CRS, DN, CKD, and RF, given that the pathogenesis of kidney disease is closely related to mitochondrial autophagy, and there is a lack of clinical reports on other types of kidney diseases such as hyperuricemia nephropathy and lupus nephritis, this field needs more clinical data to support it. The gene discussed is FUNDC1; the disease is chronic kidney disease.