BMI, body mass index; ACLF, acute-on-chronic liver failure; ALF, acute liver failure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PT (INR), prothrombin time (international normalized ratio); CTP, Chile-Turcotte-Pugh score; MELD, model for end-stage liver disease. The gene discussed is F2; the disease is acute-on-chronic liver failure.