On the other hand, Andronovici et al. mention that periodontal disease has a direct impact on the development of chronic kidney disease, when they evaluated the presence of TNF-α, IL-1β, and MMP-8 in patients with hemodialysis and periodontal disease and identified significant differences in TNF-α and MMP-8 among its groups of studies that were included [9]. The gene discussed is TNF; the disease is periodontal disorder.