Another disease that stood out in our study was the relationship between obesity and periodontal disease, due to the secretion of cytokines that maintain an inflammatory state, as demonstrated by Pradeep et al. when studying the presence of vaspin, a molecule produced by adipose tissue, in subjects with periodontal disease with and without obesity, showing a differential expression between groups [10]. This evidence concerns the gene SERPINA12 and obesity due to melanocortin 4 receptor deficiency.