Supplementary Figure S2D shows Pan-Cancer FPR3 CNV states. Heterozygous Amplification and Heterozygous Deletion are the two main types of CNV in all cancers, The former as the main type of cancer include ACC, UCS, BLCA, KICH, CESC, DLBC, GBM, BRCA and LUSC, while the former as the main type of cancer include SARC, LUAD,TGCT,OV and LGG. The COSMIC database results demonstrated that the major form of FPR3 mutations was missense mutation (35.56%), and the primary SNV was C>T (38.91%) (Supplementary Figure S2E). Here, FPR3 is linked to adrenal cortex carcinoma.