Both IL-1β and IL-10 biomarkers, as well as their ratio, showed high sensitivity and specificity and excellent potential to discriminate periodontal heath from unstable periodontitis (AUC = 0.99, 0.96, and 1.00) and stable periodontitis from unstable periodontitis (AUC 0.98, 0.99, and 1.00), respectively. The gene discussed is IL10; the disease is periodontitis.