Interestingly, the IL-1β/IL-10 ratio showed an improved diagnostic potential (AUC of 1, p  < 0.0001) to discriminate between periodontal health from unstable periodontitis (cutoff value >1.35) and stable periodontitis from unstable periodontitis (cutoff value >1.55) (Table 4). This evidence concerns the gene IL10 and periodontitis.