CD4 and rheumatoid arthritis: (VTsp) was evaluated on the percentage ofproliferation (in the CD3+, CD3+CD4+, andCD3+CD8+ cell subpopulations) and activation percentage(in the CD4CD69+, CD4HLADR+, CD8CD69+, andCD8HLADR+) from peripheral blood mononuclear cells (PBMC) from femalepatients diagnosed with RA, compared with controls, as well as the presence ofcellular mediators (IL-1β, IL-6, IL-10, and TNF-α ) in culture supernatants.