In this study, we have shown that the 7G5.TCR derived from the MC.7.G5 T-cell clone and other MR1-restricted TCRs with similar properties (e.g., tumor cell recognition and MR1 K43-dependence) robustly redirect T cells to kill cancer cells in the TCR-T format both in vitro and in vivo. This evidence concerns the gene MR1 and cancer.