STING1 and vascular disorder: For instance, patients with SAVI (STING-associated vasculopathy with onset in infancy) have a point mutation in exon 5 of STING (V147L, N154S, or V155M), which exhibit a gain-of-function phenotype and are capable of stimulating the production of an IFNβ reporter construct that causes early-onset systemic inflammation (44, 45).