Furthermore, a univariate Cox regression analysis of the pan-cancer cohorts revealed that LRPPRC expression was negatively correlated with prognosis across multiple cancer types, including adrenocortical carcinoma (ACC), kidney renal clear cell carcinoma (KIRC), and liver hepatocellular carcinoma (LIHC) (Supplementary Figure S4C). This evidence concerns the gene LRPPRC and adrenal cortex carcinoma.