TP53 and pancreatic ductal adenocarcinoma: Transcriptome analysis revealed that monocytes cultured from patients with pancreatic ductal adenocarcinoma (PDAC) exhibit fibrosis and that monocytes cultured in the presence of hydrogen peroxide (H2O2) exhibit upregulation of the p53 pathway, suggesting that MMT is induced through the production of stable p53 by reactive oxygen species (104).